This really is one of the most unique kinds of a road trips, over the Overseas Highway between continental Florida and the Florida Keys. Unlike other island nations, you can drive all the way from the U.S. proper down to the tip of the Lower Keys on over 40 connected bridges. Find out where the best places to stop are along the Overseas Highway and pack a bag. You'll want to spend a while on the Keys laid back shores, soaking in the sun.
Source: Florida Keys: Best stops on the Overseas Highway - CNN.com
